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The pathological features include synovitis, chondrocyte apoptosis, chondrocyte extracellular matrix (ECM) degradation, subchondral osteosclerosis, and osteophyte formation (Turkiewicz et al., 2014)

Translocation of opportunistic pathogens further increases intestinal permeability, allowing metabolites such as LPS to enter the circulation and activate TLR signaling, especially the TLR7/9 signaling pathway, and triggering innate immunity and type I interferon response

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I certainly dont write to offer political solutions, or solutions of any sort, but to provoke questions, to reveal ambiguities in realms where black-and-white thinking tends to prevail

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